Adding a small amount of defoamer to the foam system to increase productivity is one of the most effective and economical ways to eliminate foam. However, the addition of defoamer becomes a new risk impurity, so the residue of defoamer in the sample needs to be monitored. The difficulties in the detection of defoamer residue include: the compound with non-single component of defoamer; No UV absorption should be detected by general-purpose equipment; Low residues require highly sensitive detection methods.

Silicone defoamer can reduce the surface tension, prevent the formation and stability of bubbles, and has the characteristics of low solubility, high activity, strong stability and non-toxicity. Chromatographic analysis is the main method to test the active components of silicone defoamer. The analysis is usually performed using high performance liquid chromatography (HPLC) or gas chromatography (GC). These methods can separate out the active ingredients in the sample and perform quantitative analysis. The measured value obtained by chromatographic analysis can reflect the actual content of the active component of silicone defoamer in the sample.